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GWAS Study

A genome-wide association meta-analysis of preschool internalizing problems.

Benke KS, Nivard MG, Velders FP et al.

24839885 PubMed ID
GWAS Study Type
4596 Participants
38 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BK
Benke KS
NM
Nivard MG
VF
Velders FP
WR
Walters RK
PI
Pappa I
SP
Scheet PA
XX
Xiao X
EE
Ehli EA
PL
Palmer LJ
WA
Whitehouse AJ
VF
Verhulst FC
JV
Jaddoe VW
RF
Rivadeneira F
GM
Groen-Blokhuis MM
VB
van Beijsterveldt CE
DG
Davies GE
HJ
Hudziak JJ
LG
Lubke GH
BD
Boomsma DI
PC
Pennell CE
TH
Tiemeier H
MC
Middeldorp CM
Chapter II

Abstract

Summary of the research findings

Objective: Preschool internalizing problems (INT) are highly heritable and moderately genetically stable from childhood into adulthood. Gene-finding studies are scarce. In this study, the influence of genome-wide measured single nucleotide polymorphisms (SNPs) was investigated in 3 cohorts (total N = 4,596 children) in which INT was assessed with the same instrument, the Child Behavior Checklist (CBCL).

3,121 European ancestry individuals, 1,475 children from 1,031 families

Chapter III

Study Statistics

Key metrics and study information

4596
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Netherlands, Australia
Recruitment Country
Chapter IV

AI-Generated Summary

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