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GWAS Study

A pharmacogenomic investigation of the cardiac safety profile of ondansetron in children and pregnant women.

Drögemöller BI, Wright GEB, Trueman J et al.

35149390 PubMed ID
GWAS Study Type
257 Participants
53 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DB
Drögemöller BI
WG
Wright GEB
TJ
Trueman J
SK
Shaw K
SM
Staub M
CS
Chaudhry S
MF
Miao F
HM
Higginson M
GG
Groeneweg GSS
BJ
Brown J
ML
Magee LA
WS
Whyte SD
WN
West N
BS
Brodie SM
JG
Jong G'
IS
Israels S
BH
Berger H
IS
Ito S
RS
Rassekh SR
SS
Sanatani S
RC
Ross CJD
CB
Carleton BC
Chapter II

Abstract

Summary of the research findings

Ondansetron is a highly effective antiemetic for the treatment of nausea and vomiting. However, this medication has also been associated with QT prolongation. Pharmacogenomic information on therapeutic response to ondansetron exists, but no investigation has been performed on genetic factors that influence the cardiac safety of this medication.

62 Admixed, Admixed American, African, East Asian, European, First Nations, Middle Eastern, South Asian, South East Asian or unknown ancestry cases, 195 Admixed, Admixed American, African, East Asian, European, First Nations, Middle Eastern, South Asian, South East Asian or unknown ancestry controls

Chapter III

Study Statistics

Key metrics and study information

257
Total Participants
GWAS
Study Type
No
Replicated
Other admixed ancestry, African unspecified, Hispanic or Latin American, East Asian, European, South Asian, South East Asian, NR
Ancestry
Canada
Recruitment Country
Chapter IV

AI-Generated Summary

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