Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood.
Rye MS, Warrington NM, Scaman ES et al.
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Abstract
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Otitis media (OM) is a common childhood disease characterised by middle ear inflammation and effusion. Susceptibility to recurrent acute OM (rAOM; ≥ 3 episodes of AOM in 6 months) and chronic OM with effusion (COME; MEE ≥ 3 months) is 40-70% heritable. Few underlying genes have been identified to date, and no genome-wide association study (GWAS) of OM has been reported.
416 cases and 1,075 controls of European and unknown ancestry
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