Identification of genetic loci associated with Helicobacter pylori serologic status.
Mayerle J, den Hoed CM, Schurmann C et al.
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Abstract
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Importance: Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H. pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H. pylori susceptibility.
2,623 European ancestry high titer cases, 7,862 European ancestry low or no titer controls
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