Combined linkage and association analyses identify a novel locus for obesity near PROX1 in Asians.
Kim HJ, Yoo YJ, Ju YS et al.
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Objective: Although genome-wide association studies (GWAS) have substantially contributed to understanding the genetic architecture, unidentified variants for complex traits remain an issue. One of the efficient approaches is the improvement of the power of GWAS scan by weighting P values with prior linkage signals. Our objective was to identify the novel candidates for obesity in Asian populations by using genemapping strategies that combine linkage and association analyses.
756 Mongolian ancestry individuals from 55 families
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