Menu
Currency
GWAS Study

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.

Carr DF, Bourgeois S, Chaponda M et al.

28062682 PubMed ID
GWAS Study Type
314 Participants
42 Views
Scroll to explore
Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CD
Carr DF
BS
Bourgeois S
CM
Chaponda M
TL
Takeshita LY
MA
Morris AP
CE
Castro EM
AA
Alfirevic A
JA
Jones AR
RD
Rigden DJ
HS
Haldenby S
KS
Khoo S
LD
Lalloo DG
HR
Heyderman RS
DC
Dandara C
KE
Kampira E
VO
van Oosterhout JJ
SF
Ssali F
MP
Munderi P
NG
Novelli G
BP
Borgiani P
NM
Nelson MR
HA
Holden A
DP
Deloukas P
PM
Pirmohamed M
Chapter II

Abstract

Summary of the research findings

The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

21 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls

Chapter III

Study Statistics

Key metrics and study information

314
Total Participants
GWAS
Study Type
Yes
Replicated
16 Sub-Saharan African ancestry cases, 27 African ancestry cases, 60 Sub-Saharan African ancestry controls, 8 African ancestry controls
Replication Participants
Sub-Saharan African, African unspecified
Ancestry
Malawi, Uganda, Mozambique
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

AI Summary In Progress

Our AI-generated summary of this publication is being prepared. Please check back soon.