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GWAS Study

Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.

Christophersen IE, Magnani JW, Yin X et al.

28794112 PubMed ID
GWAS Study Type
40733 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CI
Christophersen IE
MJ
Magnani JW
YX
Yin X
BJ
Barnard J
WL
Weng LC
AD
Arking DE
NM
Niemeijer MN
LS
Lubitz SA
AC
Avery CL
DQ
Duan Q
FS
Felix SB
BJ
Bis JC
KK
Kerr KF
IA
Isaacs A
MM
Müller-Nurasyid M
MC
Müller C
NK
North KE
RA
Reiner AP
TL
Tinker LF
KJ
Kors JA
TA
Teumer A
PA
Petersmann A
SM
Sinner MF
BP
Buzkova P
SJ
Smith JD
VW
Van Wagoner DR
VU
Völker U
WM
Waldenberger M
PA
Peters A
MT
Meitinger T
LM
Limacher MC
WK
Wilhelmsen KC
PB
Psaty BM
HA
Hofman A
UA
Uitterlinden A
KB
Krijthe BP
ZZ
Zhang ZM
SR
Schnabel RB
KS
Kääb S
VD
van Duijn C
RJ
Rotter JI
SN
Sotoodehnia N
DM
Dörr M
LY
Li Y
CM
Chung MK
SE
Soliman EZ
AA
Alonso A
WE
Whitsel EA
SB
Stricker BH
BE
Benjamin EJ
HS
Heckbert SR
EP
Ellinor PT
Chapter II

Abstract

Summary of the research findings

The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and both have been associated with increased risk of atrial fibrillation. Here, we explore the genetic basis of P-wave morphology through meta-analysis of genome-wide association study results for P-wave duration and P-wave terminal force from 12 cohort studies.

33,955 European ancestry individuals, 6,778 African individuals

Chapter III

Study Statistics

Key metrics and study information

40733
Total Participants
GWAS
Study Type
No
Replicated
European, African American or Afro-Caribbean
Ancestry
U.S., Germany, Netherlands
Recruitment Country
Chapter IV

AI-Generated Summary

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