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GWAS Study

A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women.

Bensen JT, Graff M, Young KL et al.

29871690 PubMed ID
GWAS Study Type
8350 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BJ
Bensen JT
GM
Graff M
YK
Young KL
SP
Sethupathy P
PJ
Parker J
PC
Pecot CV
CK
Currin K
HS
Haddad SA
RE
Ruiz-Narváez EA
HC
Haiman CA
HC
Hong CC
SL
Sucheston-Campbell LE
ZQ
Zhu Q
LS
Liu S
YS
Yao S
BE
Bandera EV
RL
Rosenberg L
LK
Lunetta KL
AC
Ambrosone CB
PJ
Palmer JR
TM
Troester MA
OA
Olshan AF
Chapter II

Abstract

Summary of the research findings

MicroRNAs (miRNAs) regulate gene expression and influence cancer. Primary transcripts of miRNAs (pri-miRNAs) are poorly annotated and little is known about the role of germline variation in miRNA genes and breast cancer (BC). We sought to identify germline miRNA variants associated with BC risk and tumor subtype among African-American (AA) women.

3,663 African American cases, 4,687 African American controls

Chapter III

Study Statistics

Key metrics and study information

8350
Total Participants
GWAS
Study Type
No
Replicated
African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

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