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GWAS Study

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.

Bihlmeyer NA, Brody JA, Smith AV et al.

29874175 PubMed ID
GWAS Study Type
95626 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BN
Bihlmeyer NA
BJ
Brody JA
SA
Smith AV
WH
Warren HR
LH
Lin H
IA
Isaacs A
LC
Liu CT
MJ
Marten J
RF
Radmanesh F
HL
Hall LM
GN
Grarup N
MH
Mei H
MM
Müller-Nurasyid M
HJ
Huffman JE
VN
Verweij N
GX
Guo X
YJ
Yao J
LR
Li-Gao R
VD
van den Berg M
WS
Weiss S
PB
Prins BP
VS
van Setten J
HJ
Haessler J
LL
Lyytikäinen LP
LM
Li M
AA
Alonso A
SE
Soliman EZ
BJ
Bis JC
AT
Austin T
CY
Chen YI
PB
Psaty BM
HT
Harrris TB
LL
Launer LJ
PS
Padmanabhan S
DA
Dominiczak A
HP
Huang PL
XZ
Xie Z
EP
Ellinor PT
KJ
Kors JA
CA
Campbell A
MA
Murray AD
NC
Nelson CP
TM
Tobin MD
BJ
Bork-Jensen J
HT
Hansen T
PO
Pedersen O
LA
Linneberg A
SM
Sinner MF
PA
Peters A
WM
Waldenberger M
MT
Meitinger T
PS
Perz S
KI
Kolcic I
RI
Rudan I
DB
de Boer RA
VD
van der Meer P
LH
Lin HJ
TK
Taylor KD
DM
de Mutsert R
TS
Trompet S
JJ
Jukema JW
MA
Maan AC
SB
Stricker BHC
RF
Rivadeneira F
UA
Uitterlinden A
VU
Völker U
HG
Homuth G
VH
Völzke H
FS
Felix SB
MM
Mangino M
ST
Spector TD
BM
Bots ML
PM
Perez M
RO
Raitakari OT
KM
Kähönen M
MN
Mononen N
GV
Gudnason V
MP
Munroe PB
LS
Lubitz SA
VD
van Duijn CM
NC
Newton-Cheh CH
HC
Hayward C
RJ
Rosand J
SN
Samani NJ
KJ
Kanters JK
WJ
Wilson JG
KS
Kääb S
PO
Polasek O
VD
van der Harst P
HS
Heckbert SR
RJ
Rotter JI
MD
Mook-Kanamori DO
EM
Eijgelsheim M
DM
Dörr M
JY
Jamshidi Y
AF
Asselbergs FW
KC
Kooperberg C
LT
Lehtimäki T
AD
Arking DE
SN
Sotoodehnia N
Chapter II

Abstract

Summary of the research findings

QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest.

83,884 European ancestry individuals, 9,610 African American individuals, 1,382 Hispanic individuals, 750 East Asian ancestry individuals.

Chapter III

Study Statistics

Key metrics and study information

95626
Total Participants
GWAS
Study Type
No
Replicated
Hispanic or Latin American, European, African American or Afro-Caribbean, East Asian
Ancestry
U.S., Croatia, Finland, Germany, Netherlands, U.K.
Recruitment Country
Chapter IV

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