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GWAS Study

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P, Abramson K et al.

30664875 PubMed ID
GWAS Study Type
253894 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CE
Cirulli ET
NP
Nicoletti P
AK
Abramson K
AR
Andrade RJ
BE
Bjornsson ES
CN
Chalasani N
FR
Fontana RJ
HP
Hallberg P
LY
Li YJ
LM
Lucena MI
LN
Long N
MM
Molokhia M
NM
Nelson MR
OJ
Odin JA
PM
Pirmohamed M
RT
Rafnar T
SJ
Serrano J
SK
Stefánsson K
SA
Stolz A
DA
Daly AK
AG
Aithal GP
WP
Watkins PB
Chapter II

Abstract

Summary of the research findings

Background & aims: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.

1,806 European ancestry cases, 133 African American cases, 109 Hispanic ancestry cases, 10,397 European ancestry controls, 1,314 African American controls, 718 Hispanic ancestry controls

Chapter III

Study Statistics

Key metrics and study information

253894
Total Participants
GWAS
Study Type
Yes
Replicated
113 Icelandic ancestry cases, 239,304 Icelandic ancestry controls
Replication Participants
African American or Afro-Caribbean, Hispanic or Latin American, European
Ancestry
U.S., Iceland
Recruitment Country
Chapter IV

AI-Generated Summary

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