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Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study.

Zhu M, Xu K, Chen Y et al.

31152121 PubMed ID
GWAS Study Type
7414 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

ZM
Zhu M
XK
Xu K
CY
Chen Y
GY
Gu Y
ZM
Zhang M
LF
Luo F
LY
Liu Y
GW
Gu W
HJ
Hu J
XH
Xu H
XZ
Xie Z
SC
Sun C
LY
Li Y
SM
Sun M
XX
Xu X
HH
Hsu HT
CH
Chen H
FQ
Fu Q
SY
Shi Y
XJ
Xu J
JL
Ji L
LJ
Liu J
BL
Bian L
ZJ
Zhu J
CS
Chen S
XL
Xiao L
LX
Li X
JH
Jiang H
SM
Shen M
HQ
Huang Q
FC
Fang C
LX
Li X
HG
Huang G
FJ
Fan J
JZ
Jiang Z
JY
Jiang Y
DJ
Dai J
MH
Ma H
ZS
Zheng S
CY
Cai Y
DH
Dai H
ZX
Zheng X
ZH
Zhou H
NS
Ni S
JG
Jin G
SJ
She JX
YL
Yu L
PC
Polychronakos C
HZ
Hu Z
ZZ
Zhou Z
WJ
Weng J
SH
Shen H
YT
Yang T
Chapter II

Abstract

Summary of the research findings

Objective: Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci in Caucasians, less is known in Asians.

1,005 Han Chinese ancestry cases, 1,257 Han Chinese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

7414
Total Participants
GWAS
Study Type
Yes
Replicated
1,378 Han Chinese ancestry cases, 3,774 Han Chinese ancestry controls
Replication Participants
East Asian
Ancestry
China
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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