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Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study.

Khawaja AP, Rojas Lopez KE, Hardcastle AJ et al.

31246245 PubMed ID
GWAS Study Type
9029 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KA
Khawaja AP
RL
Rojas Lopez KE
HA
Hardcastle AJ
HC
Hammond CJ
LP
Liskova P
DA
Davidson AE
GD
Gore DM
HT
Hafford Tear NJ
PN
Pontikos N
HS
Hayat S
WN
Wareham N
KK
Khaw KT
TS
Tuft SJ
FP
Foster PJ
HP
Hysi PG
Chapter II

Abstract

Summary of the research findings

Importance: Keratoconus is an important cause of visual loss in young adults, but little is known about its genetic causes. Understanding the genetic determinants of corneal biomechanical factors may in turn teach us about keratoconus etiology.

6,645 individuals

Chapter III

Study Statistics

Key metrics and study information

9029
Total Participants
GWAS
Study Type
Yes
Replicated
2,384 European ancestry individuals
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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