Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
Feitosa MF, Lunetta KL, Wang L et al.
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Backgrounds and aims: Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging, and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change.
3,567 European ancestry men, 4,171 European ancestry women
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