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Genome-Wide Association Study Identifies a Functional <i>SIDT2</i> Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease.

León-Mimila P, Villamil-Ramírez H, Macías-Kauffer LR et al.

34233476 PubMed ID
GWAS Study Type
4751 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

LP
León-Mimila P
VH
Villamil-Ramírez H
ML
Macías-Kauffer LR
JL
Jacobo-Albavera L
LB
López-Contreras BE
PR
Posadas-Sánchez R
PC
Posadas-Romero C
RS
Romero-Hidalgo S
MS
Morán-Ramos S
DM
Domínguez-Pérez M
OM
Olivares-Arevalo M
LP
López-Montoya P
NR
Nieto-Guerra R
AV
Acuña-Alonzo V
MG
Macín-Pérez G
BR
Barquera-Lozano R
DB
Del-Río-Navarro BE
GI
González-González I
CF
Campos-Pérez F
GF
Gómez-Pérez F
VV
Valdés VJ
SA
Sampieri A
RJ
Reyes-García JG
CM
Carrasco-Portugal MDC
FF
Flores-Murrieta FJ
AC
Aguilar-Salinas CA
VG
Vargas-Alarcón G
SD
Shih D
MP
Meikle PJ
CA
Calkin AC
DB
Drew BG
VL
Vaca L
LA
Lusis AJ
HA
Huertas-Vazquez A
VT
Villarreal-Molina T
CS
Canizales-Quinteros S
Chapter II

Abstract

Summary of the research findings

Objective: Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have examined the underlying genetic basis. Our purpose was to identify genetic variants associated with HDL-C levels and cardiovascular risk in the Mexican population.

2,335 Mexican ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

4751
Total Participants
GWAS
Study Type
Yes
Replicated
2,114 Mexican ancestry individuals, 302 Totonac and Nahua ancestry individuals
Replication Participants
Hispanic or Latin American, Native American
Ancestry
Mexico
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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