The genetic architecture of the human cerebral cortex.
Grasby KL, Jahanshad N, Painter JN et al.
Publication Details
Comprehensive information about this research publication
Authors
Abstract
Summary of the research findings
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
33,992 European ancestry individuals
Study Statistics
Key metrics and study information
AI-Generated Summary
AI-generated by DNAGENICSIndependent AI summary of health and genetic findings from the published study
Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.
AI Summary In Progress
Our AI-generated summary of this publication is being prepared. Please check back soon.
Summary
Key Findings
Health Insights
Disease Analysis
Genetic Trait Analysis
Clinical Relevance
Related Publications
Other publications that may be of interest
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Verma A
Science
Takes medication for coronary artery/ coronary heart disease?
The genetic architecture and evolution of the human skeletal form.
Kun E
Science
Forearm length to body height ratio
Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity.
Akbari P
Science
Body mass index
Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlases.
Makowski C
Science
Dorsomedial frontal area
The genetic architecture of and evolutionary constraints on the human pelvic form.
Xu L
Science
Acetabular diameter
Explore More Research
Discover the latest findings in health and genetic research