Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.
Feitosa MF, Wojczynski MK, Anema JA et al.
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Abstract
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Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) are predictors of morbidity of pulmonary and cardiovascular diseases and all-cause mortality. In addition, reduced PF is associated with elevated chronic low-grade systemic inflammation, glucose metabolism, body fatness, and low muscle strength. It may suggest pleiotropic genetic effects between PF with these age-related factors.
6,229 European ancestry females
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