Two polymorphic gene loci associated with treprostinil dose in pulmonary arterial hypertension.
Thomeas-McEwing V, Psotka MA, Gamazon ER et al.
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Abstract
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Objective: Prostacyclin infusion for pulmonary arterial hypertension (PAH) is an effective therapy with varied dosing requirements and clinical response. The major aim of this study was to determine new biologically-based predictors of prostacyclin treatment response heterogeneity.
98 European ancestry individuals
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