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GWAS Study

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.

Kelly TN, Sun X, He KY et al.

35652341 PubMed ID
GWAS Study Type
764135 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

KT
Kelly TN
SX
Sun X
HK
He KY
BM
Brown MR
TS
Taliun SAG
HJ
Hellwege JN
IM
Irvin MR
MX
Mi X
BJ
Brody JA
FN
Franceschini N
GX
Guo X
HS
Hwang SJ
DV
de Vries PS
GY
Gao Y
MA
Moscati A
NG
Nadkarni GN
YL
Yanek LR
ET
Elfassy T
SJ
Smith JA
CR
Chung RH
BA
Beitelshees AL
PA
Patki A
AS
Aslibekyan S
BB
Blobner BM
PJ
Peralta JM
AT
Assimes TL
PW
Palmas WR
LC
Liu C
BA
Bress AP
HZ
Huang Z
BL
Becker LC
HC
Hwa CM
OJ
O'Connell JR
CJ
Carlson JC
WH
Warren HR
DS
Das S
GA
Giri A
ML
Martin LW
CJ
Craig Johnson W
FE
Fox ER
BE
Bottinger EP
RA
Razavi AC
VD
Vaidya D
CL
Chuang LM
CY
Chang YC
NT
Naseri T
JD
Jain D
KH
Kang HM
HA
Hung AM
SV
Srinivasasainagendra V
SB
Snively BM
GD
Gu D
MM
Montasser ME
RM
Reupena MS
HB
Heavner BD
LJ
LeFaive J
HJ
Hixson JE
RK
Rice KM
WF
Wang FF
NJ
Nielsen JB
HJ
Huang J
KA
Khan AT
ZW
Zhou W
NJ
Nierenberg JL
LC
Laurie CC
AN
Armstrong ND
SM
Shi M
PY
Pan Y
SA
Stilp AM
EL
Emery L
WQ
Wong Q
HN
Hawley NL
MR
Minster RL
CJ
Curran JE
MP
Munroe PB
WD
Weeks DE
NK
North KE
TR
Tracy RP
KE
Kenny EE
SD
Shimbo D
CA
Chakravarti A
RS
Rich SS
RA
Reiner AP
BJ
Blangero J
RS
Redline S
MB
Mitchell BD
RD
Rao DC
IC
Ida Chen YD
KS
Kardia SLR
KR
Kaplan RC
MR
Mathias RA
HJ
He J
PB
Psaty BM
FM
Fornage M
LR
Loos RJF
CA
Correa A
BE
Boerwinkle E
RJ
Rotter JI
KC
Kooperberg C
ET
Edwards TL
AG
Abecasis GR
ZX
Zhu X
LD
Levy D
AD
Arnett DK
MA
Morrison AC
Chapter II

Abstract

Summary of the research findings

The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.

13,836 African American or Afro-Caribbean individuals, 2,956 East Asian ancestry individuals, 840 Asian ancestry individuals, 4,173 Hispanic or Latin American individuals, 28,390 European ancestry individuals, 1,261 Samoan ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

764135
Total Participants
GWAS
Study Type
Yes
Replicated
68,870 African American or Afro-Caribbean individuals, 2,551 Asian ancestry individuals, 605,223 European ancestry individuals, 21,366 Hispanic or Latin American individuals, 14,669 individuals
Replication Participants
African American or Afro-Caribbean, Hispanic or Latin American, East Asian, Asian unspecified, European, Oceanian
Ancestry
U.S., China, Taiwan, U.K., American Samoa
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

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