A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome.
Liu Q, Tang B, Zhu Z et al.
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Aims/hypothesis: The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ovary syndrome (PCOS) that is independent of BMI remains unclear in observational studies. We aimed to clarify this association using a genome-wide cross-trait approach.
upto 74,124 type 2 diabetes European ancestry cases, upto 824,006 European ancestry controls without type 2 diabetes, upto 10,074 polycystic ovary syndrome European ancestry cases, upto 103,164 polycystic ovary syndrome European ancestry controls without polycystic ovary syndrome
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