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Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.

Gong W, Guo P, Li Y et al.

36753304 PubMed ID
GWAS Study Type
956526 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

GW
Gong W
GP
Guo P
LY
Li Y
LL
Liu L
YR
Yan R
LS
Liu S
WS
Wang S
XF
Xue F
ZX
Zhou X
YZ
Yuan Z
Chapter II

Abstract

Summary of the research findings

Importance: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) hypothesized as a potential biological basis. However, the degree to which the shared genetic determinants are involved in these associations underlying the GBA is unclear.

7,045 European ancestry inflammatory bowel disease cases, 170,056 European ancestry major depressive disorder cases, 778,725 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

956526
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
Chapter IV

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