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GWAS Study

Genetic and non-genetic risk factors for early-onset pancreatic cancer.

Nodari Y, Gentiluomo M, Mohelnikova-Duchonova B et al.

36973108 PubMed ID
GWAS Study Type
11134 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

NY
Nodari Y
GM
Gentiluomo M
MB
Mohelnikova-Duchonova B
KE
Kreivenaite E
MA
Milanetto AC
SJ
Skieceviciene J
LS
Landi S
LR
Lawlor RT
PM
Petrone MC
AP
Arcidiacono PG
LM
Lovecek M
GM
Gazouli M
BM
Bijlsma MF
ML
Morelli L
KV
Kiudelis V
TM
Tacelli M
ZD
Zanette DL
SP
Soucek P
UF
Uzunoglu F
KR
Kaaks R
IJ
Izbicki J
BU
Boggi U
PR
Pezzilli R
MA
Mambrini A
PC
Pasquali C
VL
van Laarhoven HW
KV
Katzke V
CG
Cavestro GM
SC
Sperti C
LM
Loos M
LA
Latiano A
EB
Erőss B
OM
Oliverius M
JT
Johnson T
BD
Basso D
NJ
Neoptolemos JP
AM
Aoki MN
GW
Greenhalf W
VP
Vodicka P
AL
Archibugi L
VG
Vanella G
LM
Lucchesi M
TR
Talar-Wojnarowska R
JK
Jamroziak K
SM
Saeedi MA
VE
van Eijck CHJ
KJ
Kupcinskas J
HT
Hussein T
PM
Puzzono M
BS
Bunduc S
GM
Götz M
CS
Carrara S
SA
Szentesi A
TF
Tavano F
MS
Moz S
HP
Hegyi P
LC
Luchini C
CG
Capurso G
PF
Perri F
ES
Ermini S
TG
Theodoropoulos G
CG
Capretti G
PO
Palmieri O
GL
Ginocchi L
FN
Furbetta N
CF
Canzian F
CD
Campa D
Chapter II

Abstract

Summary of the research findings

Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC.

603 cases, 6,897 controls

Chapter III

Study Statistics

Key metrics and study information

11134
Total Participants
GWAS
Study Type
Yes
Replicated
309 European, East Asian, Hispanic/Latino or unknown ancestry cases, 3,325 European, East Asian, Hispanic/Latino or unknown ancestry controls
Replication Participants
European, NR, East Asian, Hispanic or Latin American
Ancestry
U.K., Lithuania, Germany, Greece, Netherlands, Czech Republic, Hungary, Japan, Ukraine, Denmark, Poland, Italy
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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