Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria.
McSweeney SM, Saklatvala J, Rispoli R et al.
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Abstract
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Urticaria is characterized by inappropriate mast cell degranulation leading to the development of wheals and/or angioedema. Twin and family studies indicate that there is a substantial heritable component to urticaria risk.
14,306 European ancestry cases, 650,664 European ancestry controls
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