Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors.
Hong JY, Han JH, Jeong SH et al.
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The polygenic risk score (PRS) is used to predict the risk of developing common complex diseases or cancers using genetic markers. Although PRS is used in clinical practice to predict breast cancer risk, it is more accurate for Europeans than for non-Europeans because of the sample size of training genome-wide association studies (GWAS). To address this disparity, we constructed a PRS model for predicting the risk of renal cell carcinoma (RCC) in the Korean population.
992 Korean ancestry cases, 3,431 Korean ancestry controls
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