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Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.

Xicota L, Cosentino S, Vardarajan B et al.

38380866 PubMed ID
GWAS Study Type
17735 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

XL
Xicota L
CS
Cosentino S
VB
Vardarajan B
MR
Mayeux R
PT
Perls TT
AS
Andersen SL
ZJ
Zmuda JM
TB
Thyagarajan B
YA
Yashin A
WM
Wojczynski MK
KS
Krinsky-McHale S
HB
Handen BL
CB
Christian BT
HE
Head E
MM
Mapstone ME
SN
Schupf N
LJ
Lee JH
BS
Barral S
Chapter II

Abstract

Summary of the research findings

Introduction: Late-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics.

3,475 individuals

Chapter III

Study Statistics

Key metrics and study information

17735
Total Participants
GWAS
Study Type
Yes
Replicated
14,260 European or unknown ancestry individuals
Replication Participants
NR, European
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

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