Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking.
Zhu H, Choi J, Kui N et al.
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Purpose: Pancreatic cancer (PC) is a deadly disease most often diagnosed in late stages. Identification of high-risk subjects could both contribute to preventative measures and help diagnose the disease at earlier timepoints. However, known risk factors, assessed independently, are currently insufficient for accurately stratifying patients. We use large-scale data from the UK Biobank (UKB) to identify genetic variant-smoking interaction effects and show their importance in risk assessment.
765 British ancestry cases, 314,747 British ancestry controls
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