Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response.
Esposito M, Minnai F, Copetti M et al.
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Abstract
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Since the beginning of the anti-COVID-19 vaccination campaign, it has become evident that vaccinated subjects exhibit considerable inter-individual variability in the response to the vaccine that could be partly explained by host genetic factors. A recent study reported that the immune response elicited by the Oxford-AstraZeneca vaccine in individuals from the United Kingdom was influenced by a specific allele of the human leukocyte antigen gene HLA-DQB1.
1,351 European ancestry individuals
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