Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome.
Akçimen F, Chia R, Saez-Atienzar S et al.
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Objective: Restless legs syndrome (RLS) is a neurological condition that causes uncomfortable sensations in the legs and an irresistible urge to move them, typically during periods of rest. The genetic basis and pathophysiology of RLS are incompletely understood. We sought to identify additional novel genetic risk factors associated with RLS susceptibility.
9,851 European ancestry cases, 38,957 European ancestry controls
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