A genome-wide association study identifies eight loci associated with intraductal papillary mucinous neoplasm progression toward malignancy.
Gentiluomo M, Corradi C, Apadula L et al.
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Abstract
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Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer, but not all IPMNs progress to cancer. The objective of this study was to identify the germline genetic variants associated with IPMN clinical progression by conducting the first genome-wide association study (GWAS) and computing a polygenic hazard score (PHS) in 338 patients with IPMN.
338 European ancestry individuals
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