Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.
Byun E, Caillier SJ, Montalban X et al.
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Abstract
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Objective: To identify promising candidate genes linked to interindividual differences in the efficacy of interferon beta therapy. Recombinant interferon beta therapy is widely used to reduce disease activity in multiple sclerosis (MS). However, up to 50% of patients continue to have relapses and worsening disability despite therapy.
99 European ancestry responders, 107 European ancestry non-responders
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