SLCO1B1 variants and statin-induced myopathy--a genomewide study.
Link E, Parish S, Armitage J et al.
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Abstract
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Lowering low-density lipoprotein cholesterol with statin therapy results in substantial reductions in cardiovascular events, and larger reductions in cholesterol may produce larger benefits. In rare cases, myopathy occurs in association with statin therapy, especially when the statins are administered at higher doses and with certain other medications.
85 European ancestry cases, 90 European ancestry controls
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