Genetically distinct subsets within ANCA-associated vasculitis.
Lyons PA, Rayner TF, Trivedi S et al.
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Abstract
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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.
914 European ancestry cases, 5,259 European ancestry controls
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