Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Hou L, Heilbronner U, Degenhardt F et al.
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Abstract
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Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.
659 European ancestry responders, 44 East Asian ancestry responders, 1,684 European ancestry non-responders, 176 East Asian ancestry non-responders
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