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GWAS Study

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

van Meurs JB, Pare G, Schwartz SM et al.

23824729 PubMed ID
GWAS Study Type
44147 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

VM
van Meurs JB
PG
Pare G
SS
Schwartz SM
HA
Hazra A
TT
Tanaka T
VS
Vermeulen SH
CI
Cotlarciuc I
YX
Yuan X
MA
Mälarstig A
BS
Bandinelli S
BJ
Bis JC
BH
Blom H
BM
Brown MJ
CC
Chen C
CY
Chen YD
CR
Clarke RJ
DA
Dehghan A
EJ
Erdmann J
FL
Ferrucci L
HA
Hamsten A
HA
Hofman A
HD
Hunter DJ
GA
Goel A
JA
Johnson AD
KS
Kathiresan S
KE
Kampman E
KD
Kiel DP
KL
Kiemeney LA
CJ
Chambers JC
KP
Kraft P
LJ
Lindemans J
MB
McKnight B
NC
Nelson CP
OC
O'Donnell CJ
PB
Psaty BM
RP
Ridker PM
RF
Rivadeneira F
RL
Rose LM
SU
Seedorf U
SD
Siscovick DS
SH
Schunkert H
SJ
Selhub J
UP
Ueland PM
VP
Vollenweider P
WG
Waeber G
WD
Waterworth DM
WH
Watkins H
WJ
Witteman JC
DH
den Heijer M
JP
Jacques P
UA
Uitterlinden AG
KJ
Kooner JS
RD
Rader DJ
RM
Reilly MP
MV
Mooser V
CD
Chasman DI
SN
Samani NJ
AK
Ahmadi KR
Chapter II

Abstract

Summary of the research findings

The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD.

44,147 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

44147
Total Participants
GWAS
Study Type
No
Replicated
European
Ancestry
U.S., Italy, Netherlands, U.K., Switzerland
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

Important: This summary is AI-generated by DNAGENICS for informational purposes only. It was not created by, affiliated with, or endorsed by the researchers behind the original publication, and is based solely on that published research. It may contain errors or omissions. DNAGENICS disclaims all liability for any inaccuracies or consequences arising from use of this information. Verify all information against the original publication. This is not professional scientific review or medical advice.

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