Genetic variants in ALDH1L1 and GLDC influence serine to glycine ratio in Hispanic children.
Krupenko SA, Cole SA, Hou R et al.
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Abstract
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Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the 10-formyltetrahydrofolate dehydrogenase enzyme in serine-to-glycine conversion.
803 Hispanic individuals
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