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Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Mozaffarian D, Kabagambe EK, Johnson CO et al.

25646338 PubMed ID
GWAS Study Type
10421 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

MD
Mozaffarian D
KE
Kabagambe EK
JC
Johnson CO
LR
Lemaitre RN
MA
Manichaikul A
SQ
Sun Q
FM
Foy M
WL
Wang L
WH
Wiener H
IM
Irvin MR
RS
Rich SS
WH
Wu H
JM
Jensen MK
CD
Chasman DI
CA
Chu AY
FM
Fornage M
SL
Steffen L
KI
King IB
MB
McKnight B
PB
Psaty BM
DL
Djoussé L
CI
Chen IY
WJ
Wu JH
SD
Siscovick DS
RP
Ridker PM
TM
Tsai MY
RE
Rimm EB
HF
Hu FB
AD
Arnett DK
Chapter II

Abstract

Summary of the research findings

Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent influences (e.g., relating to incorporation, metabolism, or intercompetition with other fatty acids) that could alter circulating concentrations and possibly modulate or mediate impacts on health.

8,013 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

10421
Total Participants
GWAS
Study Type
Yes
Replicated
1,082 African American individuals, 669 Chinese ancestry individuals, 657 Hispanic individuals
Replication Participants
European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
Ancestry
U.S.
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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