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First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

Cousminer DL, Ahlqvist E, Mishra R et al.

30254083 PubMed ID
GWAS Study Type
10590 Participants
240 Views
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CD
Cousminer DL
AE
Ahlqvist E
MR
Mishra R
AM
Andersen MK
CA
Chesi A
HM
Hawa MI
DA
Davis A
HK
Hodge KM
BJ
Bradfield JP
ZK
Zhou K
GV
Guy VC
ÅM
Åkerlund M
WM
Wod M
FL
Fritsche LG
VH
Vestergaard H
SJ
Snyder J
HK
Højlund K
LA
Linneberg A
KA
Käräjämäki A
BI
Brandslund I
KC
Kim CE
WD
Witte D
SE
Sørgjerd EP
BD
Brillon DJ
PO
Pedersen O
BH
Beck-Nielsen H
GN
Grarup N
PR
Pratley RE
RM
Rickels MR
VA
Vella A
OF
Ovalle F
MO
Melander O
HR
Harris RI
VS
Varvel S
GV
Grill VER
HH
Hakonarson H
FP
Froguel P
LJ
Lonsdale JT
MD
Mauricio D
SN
Schloot NC
KK
Khunti K
GC
Greenbaum CJ
ÅB
Åsvold BO
YK
Yderstræde KB
PE
Pearson ER
SS
Schwartz S
VB
Voight BF
HT
Hansen T
TT
Tuomi T
BB
Boehm BO
GL
Groop L
LR
Leslie RD
GS
Grant SFA
Chapter II

Abstract

Summary of the research findings

Objective: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype.

2,634 European ancestry cases, 5,947 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

10590
Total Participants
GWAS
Study Type
Yes
Replicated
345 European ancestry cases, 1,664 European ancestry controls
Replication Participants
European
Ancestry
Norway, U.K., U.S., Denmark, Finland, Sweden
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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