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GWAS Study

Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium.

Lin BM, Grinde KE, Brody JA et al.

33418499 PubMed ID
GWAS Study Type
36167 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

LB
Lin BM
GK
Grinde KE
BJ
Brody JA
BC
Breeze CE
RL
Raffield LM
MJ
Mychaleckyj JC
TT
Thornton TA
PJ
Perry JA
BL
Baier LJ
DL
de las Fuentes L
GX
Guo X
HB
Heavner BD
HR
Hanson RL
HY
Hung YJ
QH
Qian H
HC
Hsiung CA
HS
Hwang SJ
IM
Irvin MR
JD
Jain D
KT
Kelly TN
KS
Kobes S
LL
Lange L
LJ
Lash JP
LY
Li Y
LX
Liu X
MX
Mi X
MS
Musani SK
PG
Papanicolaou GJ
PA
Parsa A
RA
Reiner AP
SS
Salimi S
SW
Sheu WH
SA
Shuldiner AR
TK
Taylor KD
SA
Smith AV
SJ
Smith JA
TA
Tin A
VD
Vaidya D
WR
Wallace RB
YK
Yamamoto K
SS
Sakaue S
MK
Matsuda K
KY
Kamatani Y
MY
Momozawa Y
YL
Yanek LR
YB
Young BA
ZW
Zhao W
OY
Okada Y
AG
Abecasis G
PB
Psaty BM
AD
Arnett DK
BE
Boerwinkle E
CJ
Cai J
YC
Yii-Der Chen I
CA
Correa A
CL
Cupples LA
HJ
He J
KS
Kardia SL
KC
Kooperberg C
MR
Mathias RA
MB
Mitchell BD
ND
Nickerson DA
TS
Turner ST
VR
Vasan RS
RJ
Rotter JI
LD
Levy D
KH
Kramer HJ
KA
Köttgen A
NT
Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium None
TK
TOPMed Kidney Working Group None
RS
Rich SS
LD
Lin DY
BS
Browning SR
FN
Franceschini N
Chapter II

Abstract

Summary of the research findings

Genetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants.

8,459 African American individuals, 1,182 Hispanic/Latino individuals, 2,208 East Asian ancestry individuals, 11,837 European ancestry individuals, 46 Native American ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

36167
Total Participants
GWAS
Study Type
Yes
Replicated
2,637 East Asian ancestry individuals, 6,767 Hispanic/Latino individuals, 3,031 Native American ancestry individuals
Replication Participants
African American or Afro-Caribbean, Hispanic or Latin American, East Asian, European, Native American
Ancestry
U.S., Taiwan
Recruitment Country
Chapter IV

AI-Generated Summary

AI-generated by DNAGENICS

Independent AI summary of health and genetic findings from the published study

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