Genome-wide association analyses of common infections in a large practice-based biobank.
Jiang L, Kerchberger VE, Shaffer C et al.
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Introduction: Infectious diseases are common causes of morbidity and mortality worldwide. Susceptibility to infection is highly heritable; however, little has been done to identify the genetic determinants underlying common infectious diseases. One GWAS was performed using 23andMe information about self-reported infections; we set out to confirm previous loci and identify new ones using medically diagnosed infections.
2,434 European ancestry cases, 12,170 European ancestry controls
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