Gamma-glutamyl-leucine levels are causally associated with elevated cardio-metabolic risks.
Wu Q, Li J, Zhu J et al.
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Abstract
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Objective: Gamma-glutamyl dipeptides are bioactive peptides involved in inflammation, oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has been extensively reported to be associated with the risk of cardio-metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes. However, the causality remains to be uncovered. The aim of this study was to explore the causal-effect relationships between Gamma-Glu-Leu and metabolic risk.
1,062 East Asian ancestry individuals
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