Genome-wide association study identifies novel loci associated with skin autofluorescence in individuals without diabetes.
Vollenbrock CE, Roshandel D, van der Klauw MM et al.
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Abstract
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Skin autofluorescence (SAF) is a non-invasive measure reflecting accumulation of advanced glycation endproducts (AGEs) in the skin. Higher SAF levels are associated with an increased risk of developing type 2 diabetes and cardiovascular disease. An earlier genome-wide association study (GWAS) revealed a strong association between NAT2 variants and SAF. The aim of this study was to calculate SAF heritability and to identify additional genetic variants associated with SAF through genome-wide association studies (GWAS).
27,254 European ancestry individuals
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