Significant association between HLA-B*35:01 and onset of drug-induced liver injury caused by Kampo medicines in Japanese.
Nakamura R, Arakawa N, Tanaka Y et al.
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Aim: Drug-induced liver injury (DILI) is a severe and life-threatening immune-mediated adverse effect, occurring rarely among treated patients. We examined genomic biomarkers in the Japanese population that predict the onset of DILI after using a certain class of drugs, such as Kampo products (Japanese traditional medicines).
231 Japanese ancestry cases, 2,994 Japanese ancestry controls
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