A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression.
Kiewa J, Mortlock S, Meltzer-Brody S et al.
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Introduction: Sex steroid hormone fluctuations may underlie both reproductive disorders and sex differences in lifetime depression prevalence. Previous studies report high comorbidity among reproductive disorders and between reproductive disorders and depression. This study sought to assess the multivariate genetic architecture of reproductive disorders and their loading onto a common genetic factor and investigated whether this latent factor shares a common genetic architecture with female depression, including perinatal depression (PND).
22,644 European ancestry cases, 175,305 European ancestry controls
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