Genomewide association study for onset age in Parkinson disease.
Latourelle JC, Pankratz N, Dumitriu A et al.
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Abstract
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Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invaluable therapeutic targets to delay the disease, we sought to identify such genetic modifiers using a genomewide association study in familial PD. There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age.
857 European ancestry familial cases, 440 idiopathic cases
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