Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy.
Graham PS, Kaidonis G, Abhary S et al.
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Abstract
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Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopathy (DR) have been described previously, but have been difficult to replicate between studies, which have often used composite phenotypes and been conducted in different populations. This study aims to identify genetic risk factors for DME and PDR as separate complications in Australians of European descent with type 2 diabetes.
270 European ancestry cases, 435 European ancestry controls
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