Genome-wide association study of varenicline-aided smoking cessation.
Coley K, Wang Q, Packer R et al.
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Introduction: Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist with the highest therapeutic efficacy of any pharmacological smoking cessation aid and a 12-month cessation rate of 26%. Genetic variation may be associated with varenicline response, but to date, no genome-wide association studies of varenicline response have been published.
1,405 European ancestry cases, 2,074 European ancestry controls
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